InDiablo 2: Resurrected, Runes are a necessity to create Runewords, empowering your weapons and armor. Thankfully, you can upgrade Runes to create more powerful variants and combine them with other Runes and gems to create new ones. Below is a full Rune List of all of the available Runes inDiablo 2: Resurrectedas well as how to create them and what mods each Rune provides. We’ve also added the level required to equip each Rune.
Armor/Helm Mod:Lowers Stamina drain by 15%

Obtained by:Combining 3x Thul Rune and 1x Chipped Topaz Gem
Obtained by:Combining 3x Amn Rune and 1x Chipped Amethyst Gem

Obtained by:Combining 3x Sol Rune and 1x Chipped Sapphire Gem
Obtained by:Combining 3x Shael Rune and 1x Chipped Ruby Gem

Obtained by:Combining 3x Dol Rune and 1x Chipped Emerald Gem
Obtained by:Combining 3x Hel Rune and 1x Chipped Diamond Gem

Obtained by:Combining 3x Io Rune and 1x Flawed Topaz Gem
Obtained by:Combining 3x Lum Rune and 1x Flawed Amethyst Gem

Obtained by:Combining 3x Ko Rune and 1x Flawed Sapphire Gem
Obtained by:Combining 3x Fal Rune and 1x Flawed Ruby Gem

Obtained by:Combining 3x Lem Rune and 1x Flawed Emerald Gem
Obtained by:Combining 2x Pul Rune and 1x Flawed Diamond Gem

Obtained by:Combining 2x Um Rune and 1x Regular Topaz Gem
Obtained by:Combining 2x Mal Rune and 1x Regular Amethyst Gem

Obtained by:Combining 2x Ist Rune and 1x Regular Sapphire Gem
Obtained by:Combining 2x Gul Rune and 1x Regular Ruby Gem

Obtained by:Combining 2x Vex Rune and 1x Regular Emerald Gem
Obtained by:Combining 2x Ohm Rune and 1x Regular Diamond Gem

Obtained by:Combining 2x Lo Rune and 1x Flawless Topaz Gem
Obtained by:Combining 2x Sur Rune and 1x Flawless Amethyst Gem
Obtained by:Combining 2x Ber Rune and 1x Flawless Sapphire Gem
Obtained by:Combining 2x Jah Rune and 1x Flawless Ruby Gem
Obtained by:Combining 2x Cham Rune and 1x Flawless Emerald Gem
Armor/Helm/Shield Mod:Indestructible
Level Required:69
This is the fullDiablo 2: ResurrectedRune List and how to craft and combine each of them. You can use these Runes and their mods to combine into powerful Runewords as well. As it stands, in non-ladder seasons combinations work differently and require three stones and their gem.